Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you may well be wondering what caused the loss and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What type of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is essential that it have exactly the right level of chromosome material; missing or extra material during conception or in an embryo or fetus could cause a female to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number may be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother gets older.

Nearly all women who experience a miscarriage go on to possess a healthy pregnancy and never miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage is apparently increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in the past the miscarriage would have appeared to be just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason for the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Because of this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the right result for the fetus or it can be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue instead of the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new type of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. stillbirth Therefore, you’re more likely to receive results and the results are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

If a chromosome abnormality is identified, the type of abnormality found can be assessed to help answer the question: “Will this eventually me again?”. Most of the time, chromosome abnormalities in an embryo or fetus aren’t inherited and have a low chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the chance of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple start the emotional healing process, moving past the question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.

Written By TriciaRevello

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